“This is a remarkably powerful tool for examining the effects of essentially any mutation of interest in an intact animal, and in a fraction of the time required for earlier methods,” says Tyler Jacks, the David H. Such models could help researchers identify and test new drugs that target these mutations. They believe this technique could also be used for nearly any other type of cancer mutation that has been identified. Using this technique, which is based on CRISPR genome-editing technology, the researchers have created models of several different mutations of the cancer-causing gene Kras, in different organs. In an advance that could help scientists make a dent in that long list of unexplored mutations, MIT researchers have developed a way to easily engineer specific cancer-linked mutations into mouse models. However, for the vast majority of those mutations, researchers are unsure of how they contribute to cancer because there’s no easy way to study them in animal models.
Mississippi Veterinary Research and Diagnostic Laboratory Faculty are members of the MSU CVM Pathobiology and Population Medicine Department.Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. MVRDL is accredited by the American Association of Veterinary Laboratory Diagnosticians and is a member of the National Animal Health Laboratory Network, which is a partnership of federal and state laboratories governed by the US Department of Agriculture.
The MVRDL provides services in anatomic pathology, clinical pathology, microbiology, molecular diagnostics, serology and virology.
The MVRDL focuses on all species except birds, which are handled by the Lab’s counterpart, the Poultry Research and Diagnostic Lab (PRDL) housed at the same location.
The MVRDL, which is administratively housed within the MSU CVM Department of Pathobiology & Population Medicine but actually located in Pearl, provides surveillance and diagnostic services in support of practicing veterinarians, individual producers, pet owners and the livestock industry, as well as tests to satisfy state and federal regulations regarding animal health, transportation, and export. The Mississippi Veterinary Research and Diagnostic Laboratory has one mission: to protect the health of animals, humans and the state’s agricultural economy.
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